A hefty 10-game schedule is on tap as the second week of the 2026 NFL preseason continues on Saturday. The first game kicks off at noon ET when the Commanders take on the Lions in Detroit. Three games follow at 1 p.m. ET, with Bills vs. Browns, Falcons vs. Colts and Ravens vs. Vikings. The night’s action closes out at 10 p.m. ET when the Cowboys battle the Cardinals. The widest line has the Buccaneers (-5.5) over the Chiefs, while the closest are at -1.5 in four other matchups  Bet NFL games at DraftKings. Claim their new user offer here:

Most teams are relatively conservative playing their starters in the NFL preseason, so there are some tough calls to make when evaluating the NFL odds. All of the updated Week 2 NFL preseason lines are listed below, and SportsLine’s Matt Severance has locked in his best NFL picks for Saturday’s action. 

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Matt Severance is a well-connected writer and high-volume handicapper who has worked in the industry since 2005. After joining SportsLine, Matt quickly established himself as a top expert in multiple sports. He has returned $1,437 to $100 players over the past three NFL seasons. Anybody following his NFL betting picks at sportsbooks and on betting sites could have seen strong returns.    

Now, Severance has turned his attention to the latest Week 2 NFL preseason and NFL betting lines and locked in betting picks for every NFL matchup on Saturday. Head here to see his picks. 

Top NFL preseason predictions for Week 2 on Saturday 

One of Severance’s strongest Week 2 NFL picks for Saturday is Browns (-2.5) over Bills, as Cleveland is in the midst of a quarterback competition. 

Second-year veterans Dillon Gabriel and Shedeur Sanders, along with rookie Taylen Green are battling 10th-year veteran Deshaun Watson to be the Browns’ starting quarterback. 

“It sounds like it’s backups for the Bills, while Cleveland has a quarterback competition ongoing between Shedeur Sanders and Deshaun Watson, which to me is like being forced to choose to listen to either that old AOL sign-on screech or nails on a chalkboard,” Severance said. “Sanders apparently will play the first half, Watson the third and then Dillon Gabriel the fourth.” See which other teams to pick here.

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How to make Week 2 NFL preseason picks for Saturday

Severance has locked in two more best bets for Saturday, including backing a pair of underdogs who should have motivational edge on Saturday. You can get all his picks at SportsLine.

So what Week 2 NFL preseason picks can you make with confidence, and which underdog pick should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven expert who has returned $1,437 over the past three NFL seasons, and find out.

Week 2 NFL preseason betting odds for Saturday, Aug. 22

Get Week 2 NFL preseason best bets at SportsLine

Commanders at Lions (-1.5, 36.5)
Bills at Browns (-3, 36.5)
Ravens at Vikings (-3.5, 36.5)
Falcons at Colts (-3, 36.5)
Saints at Rams (+1.5, 37.5)
Giants at Dolphins (+3, 36.5)
Bears at Bengals (+1.5, 36.5)
Eagles at Patriots (+1.5, 36.5)
Chiefs at Buccaneers (-5.5, 37.5)
Cowboys at Cardinals (-1.5, 37.5)