The second week of the 2026 NFL preseason continues on Friday with a three-game slate. The first game kicks off at 7 p.m. ET when the Jets take on the Steelers in Pittsburgh. The Panthers at Jaguars follows at 7:30 p.m. ET, with Packers at Broncos closing out the night’s action at 9 p.m. ET. The latest NFL odds for preseason action on Friday list the Broncos at -5.5. The other two lines are at -1.5. Bet NFL games at DraftKings. Claim their new user offer here:

Most teams are relatively conservative playing their starters in the NFL preseason, so there are some tough calls to make when evaluating the NFL odds. All of the updated Week 2 NFL preseason lines are listed below, and SportsLine’s Matt Severance has locked in his best NFL picks for Friday’s action. 

Visit our DraftKings promo code review to see their latest offers and get started.

Matt Severance is a well-connected writer and high-volume handicapper who has worked in the industry since 2005. After joining SportsLine, Matt quickly established himself as a top expert in multiple sports. He has returned $1,437 to $100 players over the past three NFL seasons. Anybody following his NFL betting picks at sportsbooks and on betting sites could have seen strong returns.    

Now, Severance has turned his attention to the latest Week 2 NFL preseason and NFL betting lines and locked in betting picks for every NFL matchup on Friday. Head here to see his picks. 

Top NFL preseason predictions for Week 2 on Friday 

One of Severance’s strongest Week 2 NFL picks for Friday is Steelers (+1.5) over Jets, as Penn State product Drew Allar looks to continue his strong preseason play. 

Allar, a third-round pick, was impressive in Week 1 against the Green Bay Packers. He completed 10 of 13 passes for 153 yards and two touchdowns in a 28-9 win. 

“Pittsburgh’s Aaron Rodgers won’t play because he never does in the preseason,” Severance said. “But one of the big stories of Week 1 was Steelers rookie QB Drew Allar, a third-rounder out of Penn State. I think calling him a steal is just a tad premature, but Allar might already be more talented than anything the Jets have. And Allar should play a lot. Will Howard is no slouch, either.” See which other teams to pick here.

New to sports trading? Visit our Kalshi promo code review to see their latest offers and get started. Claim the Kalshi signup offer here now:

How to make Week 2 NFL preseason picks for Friday

Severance has locked in two more best bets for Friday, including backing a pair of underdogs who should have motivational edge on Friday. You can get all his picks at SportsLine.

So what Week 2 NFL preseason picks can you make with confidence, and which underdog pick should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven expert who has returned $1,437 over the past three NFL seasons, and find out.

Week 2 NFL preseason betting odds for Friday, Aug. 21

Get Week 2 NFL preseason best bets at SportsLine

Jets at Steelers (+1.5, 37.5)
Panthers at Jaguars (+1.5, 37.5)
Packers at Broncos (-5.5, 40.5)