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Our editors have researched and tested clean supplements for years. These are our picks for supplements made with quality, third-party-tested ingredients to help support GLP-1 naturally.
GLP-1 has quickly become a catchall for the synthetic medications used to treat diabetes and obesity. However, that only tells part of the story. Popular injectables like Ozempic and Mounjaro mimic the hormone known as GLP-1, but many are turning to supplements to help lower blood sugar naturally in lieu of the medication.
What is GLP-1 — and is it naturally occurring?
Glucagon-like peptide-1 (GLP-1) is a naturally occurring hormone, and after eating, it performs a number of tasks: It signals the pancreas to release insulin, which lowers the amount of sugar in your blood and keeps your blood sugar from spiking. It also slows digestion, and tells your brain you’re full.
What should you look for in a natural GLP-1 supplement?
If you want to skip synthetic hormones, look for supplements promoting metabolic health and lowering your blood sugar. Brands such as Pendulum have developed a probiotic blend to address glucose spikes and digestive issues, among other concerns, while Sakara has created a snackable gummy derived from natural ingredients to curb sugar cravings and give you a boost of energy.
Our criteria:
After researching, corresponding with brands, and combing through customer reviews, our editors have chosen our favorite brands with supplements to support healthy glucose and metabolism naturally. We update this list regularly with new, emerging favorites, and all of our picks are evaluated to meet the following criteria:
- SCIENCE-BACKED | For this guide, we’ve prioritized brands that are backed by accredited clinicians and scientists with years of experience.
- THIRD-PARTY TESTED | Each brand uses high-quality ingredients without synthetic fillers, artificial flavors, dyes, parabens, or unnecessary additives. The options on this list offer third-party testing so you know what you’re taking.
To fully support your health, our editors have spent years testing and curating our picks for the best women’s multivitamins, protein powders, electrolytes, and probiotics.
1. Thorne
Best For | Holistic metabolic health
Key Ingredients | Curcumin phytosome, bergamot phytosome
Prices starting at | $60 for a two-month supply
We often recommend Thorne because of its accessibility and high-quality ingredients. Thorne’s Metabolic Health supplement is powered by two botanical extracts, bergamot and curcumin, both of which are derived from sunflowers. The two key ingredients work in tandem to “balance the normal inflammatory responses and hormones that can sabotage a weight management program,” according to the brand. Sold at lots of big-box stores, you can easily secure your purchase online or directly in-store if you need an immediate restock.
Take two of these capsules per day, ideally in the morning and before bed, or the brand recommends consulting with your healthcare provider on the proper dosage. Reviewers rave that these supplements are easy to digest and said they noticed results soon after adding them to their routine. For even more confidence in the company, Thorne’s supplement is NSF Sport certified, and all of their products are manufactured in Summerville, South Carolina. As part of their quality assurance process, supplements like this one are all third-party tested as well.
Customer Review | “Easy to digest capsules with no aftertaste or post-ingestion burps. I think this is absolutely keeping my metabolic health in check, especially when I have days that I am more stagnant than others. I will continue to purchase this as part of my daily supplement stack.” – Jamie A. (Read more reviews.)
2. Pendulum
Best For | Managing blood sugar spikes
Key Ingredients | Clostridium butyricum, Clostridium beijerinckii, Bifidobacterium infantis, Anaerobutyricum hallii, Akkermansia muciniphila
Prices starting at | $99 for 60 capsules
Founded by a mom and scientist with a Ph.D. in biochemistry and microbiology, Pendulum takes a natural and scientific approach to health and wellness. There are plenty of supplements purporting to help support the GLP-1 hormone, but Pendulum’s probiotic blend specifically targets those dreaded post-meal glucose spikes. Three of the strains — Clostridium butyricum, Anaerobutyricum hallii, and Clostridium beijerinckii — produce butyrate, a naturally occurring fatty acid that provides benefits to your digestive and immune systems. In a double-blinded, placebo-controlled clinical trial, Pendulum Glucose Control users reduced their A1C (a measure of average blood sugar over three months) by 0.6 points, on average, and post-meal glucose spikes decreased by 32.5 percent.
You’ll want to take two capsules per day, and Pendulum says to “use only under physician supervision as part of a diabetes management plan.” This product is not intended for weight loss, but increasing GLP-1 is one “pro” provided by the supplement.
Customer Review | “The first thing I celebrated was an immediate 0.3 reduction in my A1C, officially bringing me back into the normal range. But the real game-changer? My lifelong weakness for sugar has simply vanished. I finally have a ‘Stop’ button that works, allowing me to enjoy an occasional dessert without losing control. My overall appetite has decreased, and my A1C has remained perfectly normal for an entire year. Honestly, it feels like my whole brain and metabolism have been completely—and happily—re-wired!” – Rebeca (Read more reviews.)
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3. Ora
Best For | Subscription service
Key Ingredients | Eriomin lemon flavonoids extract, Morosil Sicilian red orange extract, Reducose mulberry leaf extract, Feiolix feijoa powder
Prices starting at | $60 for one-month supply
Ora’s best-selling supplement is made with four clinically studied botanical ingredients to support an increase in natural GLP-1 levels and decrease in post-meal blood sugar levels. In fact, a study showed that 40 percent of participants had a “lower natural post-meal glucose and insulin response on Reducose [mulberry leaf extract].” Known as OraGlucose Guard and OraBurn, these trademarked ingredients are made to slow carbohydrate digestion, balance blood sugar, and help your body burn fat (among other benefits).
The brand says it’s best to take two capsules within 10 minutes of starting your lunch, which should be the largest meal of the day. Subscriptions are available, allowing you to save 20 percent on your purchase and keep you on a consistent delivery schedule. This is one of many products offered by the brand (and recommended by our editors). The lineup also includes a top-notch organic probiotic and surprisingly tasty vegan protein powder.
Customer Review | “Really helped with bloat and digestion right away and a few weeks in have felt less hungry throughout the day!” – Rivka B. (Read more reviews.)
4. Sakara
Best For | Gummy to curb cravings
Key Ingredients | Dyglofit (African spicefruit extract), Supresa (saffron extract), blend of cinnamon bark extract and pomegranate fruit extract
Prices starting at | $51 for one-month supply
Sakara makes some of the most delicious and nutritious food deliveries we’ve ever tried, and you don’t want to sleep on their supplements. Take these pomegranate-flavored gummies, made to support and increase levels of GLP-1 and prevent cravings and blood sugar spikes. Chewy and tasty, the no-sugar-added recipe is a welcome addition to any self-care routine, and packed with clinically tested botanical ingredients. Plus, the brand reports an impressive 70 percent of testers had a “decreased desire to snack between meals.”
Each one-month delivery contains 28 servings, and Sakara suggests taking two gummies daily in between meals. You can make a one-time purchase of $60, or purchase one of two subscriptions: save 15 percent with a monthly delivery, or save 20 percent with a three-month delivery. Sakara is known for sustainability, too, and these pouches are printed with eco-friendly films and technology.
Customer Review | “Metabolism bites taste good and seem to be working. I’ve been taking them for a little under a month, and I can honestly say have not craved anything sweet. I’ve also noticed I’ve been feeling fuller longer in between meals.” – Ariel G. (Read more reviews.)
5. Cymbiotika
Best For | Bioavailable ingredients
Key Ingredients | Epigallocatechin gallate (EGCG), Oleoylethanolamide (OEA), dihydroberberine, moringa leaf powder, theobromine
Prices starting at | $46 for one-month supply
With a focus on clean, simple ingredients, Cymbiotika prioritizes bioavailable (a.k.a. highly absorbable) formulas. The new-and-improved metabolism supplement is no exception. It now contains dihydroberberine, moringa leaf powder, and theobromine. A form of berberine, dihydroberberine is five times more bioavailalable and “supports health blood sugar levels and metabolic health with fewer side effects,” according to the brand. The product was reformulated and reintroduced in January 2025, and now includes three capsules per serving as opposed to two.
Cymbiotika says to take three capsules 30 minutes before your biggest meal of the day, or to seek dosage advice from your healthcare provider. A one-time purchase is $66 for a one-month supply, or you can save 30 percent when you subscribe.
Customer Review | “This is a great supplement that gave me a consistent burst of energy around the usual slump time which happens about an hour after lunch. I feel that is has boosted my energy levels, since my metabolism has slowed down as I approach my early 40’s and I’ve noticed a difference after usage, and I no longer seem to be fatigue at all. I am going to continue using Metabolic Health regularly since I really feel quite a difference.” – Anne M. P. (Read more reviews.)
6. Codeage
Best For | Budget-friendly supplements
Key Ingredients | Akkermansia muciniphila, Bifidobacterium infantis, berberine HCI, chromium, decaffeinated green tea leaf extract
Prices starting at | $40 for one-month supply
Codeage is a company founded with a mission to develop what they refer to as the “Longevity Code.” A four-pillar system, each one targets specific areas for your health and wellness: daily foundation, structural integrity, cellular longevity, and system balance. The GLP-Advantage+ supplements fall into the fourth segment. Focusing on “trim and glow,” these capsules combine probiotics (100 million AFU‡ of Akkermansia muciniphila and Bifidobacterium infantis), decaffeinated green tea extract, and bioactive berberine to allow you to reach your wellness goals. Several reviewers shared that it significantly improved their glucose levels.
Each serving is two capsules and one bottle of GLP-Advantage+ contains a one-month supply. Take two capsules per day with 8 ounces of water or another beverage 30 minutes before your largest meal, or as directed by your healthcare provider. These are only available as a one-time purchase, and no subscriptions are available, though they are the most cost-effective option on our list.
Customer Review | “I’m really impressed with the results of this GLP supplement. The My glucose metabolism and overall metabolic health are much improved. I would recommend this to anyone looking to have more energy throughout the day.” – Ken (Read more reviews.)
7. Supergut
Best For | Powder formula
Key Ingredients | Oat beta glucan, Solnul resistant potato starch, unripened green bananas, soluble vegetable fiber
Prices starting at | $26 for 20 servings
Sometimes, you don’t want to think about your daily supplements. Supergut makes it easier than ever, thanks to this prebiotic fiber blend, which you can add to your water, morning coffee, or yogurt. The fiber-rich formula features plant-based ingredients to aid digestion and help you manage your appetite. Oat beta glucan is particularly essential for those looking to lower blood sugar, as it targets maintaining a healthy balance in glucose levels and also promotes heart health.
Add one scoop of Supergut’s GLP-1 Daily Support to your drink or food (the brand recommends oatmeal or yogurt). Because it’s available in blood orange, raspberry lemon, and watermelon lime, or unflavored, it’s easy to pick the one you’ll find the most delicious. Purchase canisters as a one-time or subscription purchase, or select on-the-go packets for GLP-1 support while you’re running errands or traveling.
At the time of publishing, Supergut was offering a free watermelon lime canister to customers who spend $65 or more on the brand’s website.
Customer Review | “I was really glad I got a chance to try the Supergut GLP-1 daily support prebiotic fiber. It literally dissolves into any drink. I noticed after taking this consistently, my gut feels calmer and I feel less bloated. The watermelon lime flavor is so delicious and refreshing that with just water, you get a refreshing drink!” – DeepikaC (Read more reviews.)
Featured image is from Cymbiotika
Blake Bakkila is a freelance writer and editor with eight years of experience covering topics including baby and parenting, food, health, pop culture, and interior design. In addition to The Good Trade, her work has appeared in the digital publications of Architectural Digest, Sunset, Good Housekeeping, and more. She highlighted the best, most game-changing baby and parenting products as the former senior commerce editor at What to Expect and BabyCenter, and she’s also held editorial positions at Good Housekeeping, Health, Real Simple, and People. Blake holds a bachelor’s in journalism from Northwestern University’s Medill School of Journalism. When she’s not typing, you can usually find her watching anything on Bravo, entertaining her son Rhode, and conducting field research on the best ice cream in Southern California.
