A recent example was published in 2025 by researchers at the European X-Ray Free-Electron Laser Facility near Hamburg, among other institutions. They cooled iodopyridine, an organic molecule consisting of 11 atoms, almost to absolute zero and hammered it with a laser pulse to break its atomic bonds. The team found that the motions of the freed atoms were correlated, indicating that, despite its chilled state, the iodopyridine molecule had been vibrating. “That was not initially the main goal of the experiment,” said Rebecca Boll, an experimental physicist at the facility. “It’s basically something that we found.”

Perhaps the best-known effect of zero-point energy in a field was predicted by Hendrick Casimir in 1948, glimpsed in 1958, and definitively observed in 1997. Two plates of electrically uncharged material—which Casimir envisioned as parallel metal sheets, although other shapes and substances will do—exert a force on each other. Casimir said the plates would act as a kind of guillotine for the electromagnetic field, chopping off long-wavelength oscillations in a way that would skew the zero-point energy. According to the most accepted explanation, in some sense, the energy outside the plates is higher than the energy between the plates, a difference that pulls the plates together.

Quantum field theorists typically describe fields as a collection of oscillators, each of which has its own zero-point energy. There is an infinite number of oscillators in a field, and thus a field should contain an infinite amount of zero-point energy. When physicists realized this in the 1930s and ’40s, they at first doubted the theory, but they soon came to terms with the infinities. In physics—or most of physics, at any rate—energy differences are what really matters, and with care physicists can subtract one infinity from another to see what’s left.

That doesn’t work for gravity, though. As early as 1946, Wolfgang Pauli realized that an infinite or at least gargantuan amount of zero-point energy should create a gravitational field powerful enough to explode the universe. “All forms of energy gravitate,” said Sean Carroll, a physicist at Johns Hopkins University. “That includes the vacuum energy, so you can’t ignore it.” Why this energy remains gravitationally muted still mystifies physicists.

In quantum physics, the zero-point energy of the vacuum is more than an ongoing challenge, and it’s more than the reason you can’t ever truly empty a box. Instead of being something where there should be nothing, it is nothing infused with the potential to be anything.

“The interesting thing about the vacuum is every field, and therefore every particle, is somehow represented,” Milonni said. Even if not a single electron is present, the vacuum contains “electronness.” The zero-point energy of the vacuum is the combined effect of every possible form of matter, including ones we have yet to discover.

Original story reprinted with permission from Quanta Magazine, an editorially independent publication of the Simons Foundation whose mission is to enhance public understanding of science by covering research developments and trends in mathematics and the physical and life sciences.