With the natural look firmly in, there has been an increase in the number of regenerative treatments offered in-office by plastic surgeons and dermatologists alike. Here, we take a look at the buzziest and most innovative in aesthetic treatments for the skin and break down cost, downtime and doctors who are offering these cutting-edge services.

Diamond InstaFacial

The Diamond InstaFacial combines light laser resurfacing, platelet-rich plasma/fibrin (PRP/PRF) injections derived from the patient’s own blood, PRP-infused microneedling, and a micronized collagen mask to stimulate collagen, elastin and hyaluronic acid production at multiple depths of the skin. 

Board-certified plastic surgeon Dr. Jason Diamond says of the treatment, “We spent years developing and honing the Diamond InstaFacial in order to target the multiple age-related and aesthetic concerns with a single treatment. I have always believed in a multimodality approach. In my experience, this achieves more powerful, synergistic results for the patient.”

Downtime: 2 to 3 days

Price: Starts at $4,500

Address: The Diamond Face Institute, 9400 Brighton Way, Penthouse Suite, Beverly Hills

Stem Cell Harvesting, Banking and Rejuvenation

The process begins with the collection of approximately 50 hair follicles, a rich source of stem cells. These cells are cryogenically preserved at -196°C, maintaining their potency and allowing patients to bank their cells for future regenerative therapies. Using the patient’s own preserved stem cells, a personalized secretome serum is created — containing billions of bioactive molecules, including growth factors, exosomes, peptides and cytokines. This serum is then incorporated into treatments such as RF microneedling, laser and advanced hair restoration as a topical skin booster.

Board certified facial plastic and reconstructive surgeon Dr. Eunice Park says “Regenerative secretome is essentially the language of cellular renewal — it contains the growth factors, peptides and signaling molecules that tell the skin how to repair itself. By harvesting stem cells from hair follicles and leveraging their secretome, we’re able to deliver highly bioactive signals that support regeneration at a cellular level. This allows us to move beyond traditional treatments and into a new era of truly regenerative aesthetics.”

Downtime: None

Starting price: $1,000

Address: AIREM Aesthetic Spa & Plastic Surgery with locations in Manhattan, Syosset and Water Mill Hamptons, N.Y.

NanoFat Skin Optimization

During this minimally invasive procedure, the patient’s own fat is extracted using liposuction, then processed in order to transform it into “nanofat” – smaller fat particles that are rich in growth factors and stem cells. Thereafter, the nanofat is injected and microneedled into target areas of the face, neck, chest and/or hands with skin laxity, depending on the patient’s anatomy and aesthetic goals.

Dr. Diamond says “Bioregenerative medicine has been an integral part of my practice since its inception. Aside from our signature Diamond InstaFacial, NanoFat is something I have been using for years and years. It is now becoming more widespread and increasingly recognized for its bioregenerative properties in skin rejuvenation, as it is a refined form of autologous fat grafting.”

Downtime: 48 hours to 1 week, depending on swelling

Pricing: Available on request

Address: The Diamond Face Institute, 9400 Brighton Way, Penthouse Suite, Beverly Hills

P.E.A.R.L. by AnteAGE

With PDRN (a regenerative compound derived from salmon sperm cells), exosomes, antioxidants, growth factors and Amino Acids, P.E.A.R.L. is designed to accelerate healing, boost tissue regeneration and improve skin texture when combined with in-office treatments like microneedling.

“True luxury in aesthetics is subtlety: results that are seen, but not detected. Regenerative treatments like P.E.A.R.L. allow us to achieve that by improving skin quality at its foundation,” says board certified plastic surgeon Dr. Berry Fairchild.

Downtime: 1 to 2 days

Starting price: Available on request

Address: Berry Fairchild, 9230 Katy Freeway, Suite 600, Houston

Ariessence pure PDGF+

Ariessence pure PDGF+ is a topical formulation designed to complement in office treatments. Featuring platelet-derived growth factor, or PDGF — a naturally occurring protein found in the body — combined with sterile hyaluronic acid, it can be used as part of a skin care routine following procedures such as microneedling, laser skin resurfacing and chemical peels to enhance the visible results of aesthetic treatments. 

According to board-certified dermatologist Dr. Michelle Henry, “I like Ariessence Pure PDGF+ because it delivers bioidentical growth factors that enhance skin repair and optimize post-procedure results. It’s a sophisticated way to support collagen production and healing without the inconsistency we may see with other regenerative options.”

Downtime: Primarily associated with the underlying procedure and will vary depending on treatment type and intensity.

Starting price or range: Available on request

Address: Skin & Aesthetic Surgery of Manhattan, 120 East 56th Street, Unit 1500, New York

Everesse

Everesse is a monopolar radiofrequency treatment designed to lift, volumize and tighten skin by delivering controlled 6.78 MHz RF energy in a single pulse, targeting both the superficial and deeper layers of the dermis to stimulate collagen and elastin production.

According to Park, “Monopolar radiofrequency is one of the most effective ways to stimulate collagen and achieve meaningful skin tightening without downtime. Advanced technologies coming out of South Korea, such as Xtherma and Everesse, allow us to deliver energy more precisely and comfortably, making the treatment both efficient and highly tolerable. When used as part of a customized, multimodal skin tightening protocol, it becomes a powerful tool for long-term skin quality and structural support.”

Downtime: Minimal to none

Starting price: $3,200

Address: AIREM Aesthetic Spa & Plastic Surgery with locations in Manhattan, Syosset and Water Mill Hamptons, N.Y.