Ukraine has come under a massive Russian missile and drone attack with waves of explosions echoing through the capital, Kyiv, in the early hours of Monday morning as air raids killed at least five people across the country.

Among targets hit in the sustained wave of strikes were the city’s historic Dormition Cathedral within the Kyiv Pechersk Lavra, one of Ukraine’s most significant religious sites, as well as residential buildings across the city.

Footage from the Perchersk Lavra, a Unesco world heritage site, showed towering flames licking up towards its domes. Six people were reported injured.

“[T]he roof of one of the holiest places in the Christian world – the Dormition Cathedral of the Kyiv Pechersk Lavra – is burning,” Metropoliton Epiphanius, head of the Orthodox Church of Ukraine, wrote on X.

Yulia Svyrydenko, the prime minister, posted a picture of the monastery building in flames and wrote: “A brutal assault on our people ‌and our heritage. This is the true face of Russia’s Orthodox values.

“We ask for prayers for the salvation of the shrine from destruction. Another Russian crime against humanity, against history, against Christianity.”

Damage was reported at 16 locations across the capital amid the sound of interceptor launches and explosions that shook windows in the city centre.

“New launches targeting the capital keep being recorded,” said Tymur Tkachenko, head of Kyiv’s military administration, urging people to remain in shelters as at least 10 people were reported injured.

Attacks across Ukraine came after the Russian president, Vladimir Putin, had warned that Moscow would target Ukraine with “systemic” strikes, and amid evidence of mounting battlefield setbacks for Russia.

The strikes follow a period of relative quiet in Kyiv in recent days as Moscow prepared its drone and missile forces for the latest in a recent series of massive air attacks.

Outside the capital, at least five people were killed in the city of Kharkiv in what appeared to be a double tap strike targeting emergency responders.

Poland, an EU and Nato member, scrambled fighter jets and put ground-based air defence systems and radar reconnaissance on a state of readiness, the Polish armed forces said on Monday morning.

The strikes came after the Ukrainian president, Volodymyr Zelenskyy, said on Sunday that he had ⁠spoken to Donald Trump ahead of ​a G7 meeting in France this ​week and discussed efforts to achieve an end to the ​more than four-year war.

Trump also told Putin on Sunday that ending the conflict in Ukraine was ​vital and he was ‌ready to help, the ​Kremlin said.

Progress towards a ​peace agreement in Ukraine has been slow, with US officials and mediators concentrating on the conflict in the Middle East. US and Iranian officials said on Sunday they had agreed on a peace framework to end their war, with the pact expected to be officially signed on Friday in Switzerland.