Ministry of National Defence says no casualties or damage after missile shot down over southern city of Gaziantep.

The Turkish Ministry of National Defence says NATO air defences have intercepted a ballistic missile launched from Iran towards Turkiye as concerns grow that the United States-Israel war against Iran will escalate.

The missile was intercepted on Monday over the Sahinbey district of Gaziantep in southern Turkiye, the ministry said in a statement. No casualties or damage were reported.

“Ankara emphasized its capability and determination to protect national airspace and border security, while warning that further escalation in the region must be avoided,” the statement said.

The ministry also urged all sides, especially Tehran, “to refrain from actions that could endanger civilians or undermine regional stability”.

Monday’s incident was the second time an Iranian ballistic missile was fired towards Turkiye since the US and Israel launched a war against Iran on February 28, according to local authorities.

The US-Israeli attacks have prompted a wave of Iranian missile and drone strikes across the wider region, including on targets in Arab Gulf countries.

Iran did not immediately comment on the Turkish ministry’s statement.

NATO spokesperson Allison Hart confirmed that the military alliance had intercepted “a missile heading to Turkiye”. “NATO stands firm in its readiness to defend all Allies against any threat,” Hart said in a post on X.

Iran denied firing a ballistic missile towards Turkiye on Wednesday after Turkish authorities said NATO air defences shot down a projectile over the Eastern Mediterranean.

NATO condemned that launch, expressing its “full solidarity” with Turkiye.

“This is a tangible demonstration of the Alliance’s ability to defend our populations against all threats, including those posed by ballistic missiles,” NATO said of the interception.

Article 5 of the alliance’s North Atlantic Treaty says an attack on one NATO country will be considered an attack on all. It also commits each NATO member state to taking action deemed necessary “to restore and maintain” security.

In an interview with the Reuters news agency last week after the first ballistic missile heading towards Turkiye was shot down, NATO chief Mark Rutte said there was no talk of invoking Article 5.

Iranian authorities have said they are firing at US military bases and other US- and Israel-linked targets across the region in self-defence, but civilian infrastructure has also been attacked.

“Iran’s targets are not just US bases; they are, in fact, primarily large-scale infrastructure and civilian targets as well,” said Rob Geist Pinfold, a lecturer in defence studies at King’s College London.

“This is not a mistake. This is by design,” Pinfold told Al Jazeera, explaining that Tehran is seeking to “unleash as much chaos as possible to destabilise the region and global markets” in an effort to force Washington to abandon the war.

“We’ve seen that Iran is targeting every single [Gulf Cooperation Council] state. It’s prepared to burn its bridges with all of them to pursue this very uncertain and high-risk strategy,” he said.

“It really shows you how Iran feels like it’s facing an existential threat. For them, this is a real do-or-die moment.”