DUBAI, United Arab Emirates (AP) — U.S. strikes hit a city Tuesday that is home to one of Iran’s main nuclear sites, sending a massive fireball into the sky, and Tehran attacked a fully loaded Kuwaiti oil tanker in the Persian Gulf.

The attacks were testament to the intensity of the war more than a month after the U.S. and Israel launched their first strikes. The conflict has left more than 3,000 dead and caused major disruptions to the world’s supply of oil and natural gas. On Tuesday, the average price of gasoline in the U.S. shot past $4 a gallon — just another sign of the war’s effects far beyond the Middle East.

U.S. President Donald Trump said countries upset by high fuel prices should “go get your own oil” as Iran maintains its chokehold on the Strait of Hormuz. He expressed his frustration on social media toward allies that have been unwilling to help the U.S. reopen the critical passageway. “Go get your own oil,” Trump wrote. He also said they should buy from the U.S. because “we have plenty.”

Trump, who has vacillated between insisting there is progress in diplomatic talks with Iran and threatening to widen the war, shared footage of the attack on Isfahan. The central city is home to one of three nuclear enrichment sites attacked by the U.S. in a 12-day war in June, and analysts believe much of Iran’s highly enriched uranium is likely stored there.

The war is roiling oil market

Iran’s stranglehold on the Strait of Hormuz, the waterway leading out of Persian Gulf through which a fifth of the world’s oil is transported during peacetime, has driven up global oil prices, as have Tehran’s attacks on regional energy infrastructure. That has shaken stock markets around the world and pushed up the cost of many basic goods.

Spot prices of Brent crude, the international standard, hovered around $106 a barrel Tuesday, up more than 45% since the war started Feb. 28.

Trump warned this week that if a ceasefire is not reached “shortly,” and if the strait is not reopened, the U.S. would broaden its offensive, including by attacking the Kharg Island oil export hub and possibly desalination plants.

Israel and the US launch a new wave of strikes on Iran

Israel and the U.S. launched a wave of strikes on Iran, hitting Tehran in the early morning.

The video shared by Trump appeared to show a massive attack on Isfahan, and NASA fire-tracking satellites suggest explosions happened in a mountainous region on the city’s southern edge. Iran has not confirmed the attack.

A satellite image taken just before the June war suggests Tehran transferred a truckload of highly enriched uranium to a nuclear facility about 20 kilometers (12 miles) from Tuesday’s strikes.