A rematch of the 2025 national championship game is on tap this Friday as Geno Auriemma and the UConn Huskies take on Dawn Staley and the South Carolina Gamecocks in the 2026 Women’s NCAA Tournament Final Four. Both top-seeded teams and rolled through their respective regions, with both teams winning every game in March Madness by at least 18 points thus far. The Gamecocks are looking for revenge after UConn dominated the title game last year 82-59. 

The game from Mortgage Matchup Center in Phoenix tips off at 7 p.m. ET. The Huskies are 7.5-point favorites in the latest UConn vs. South Carolina odds, while the over/under for total points scored is 135.5. Before making any South Carolina vs. UConn picks, check out what SportsLine college basketball experts Calvin Wetzel and Aaron Barzilai have to say.

Barzilai is a Ph.D. from Stanford who served as Director of Basketball Analytics for the Philadelphia 76ers. Eight years ago, he founded HerHoopStats.com — a groundbreaking website that unlocks insights about the women’s game. Wetzel, the site’s lead betting writer, incorporates his mathematical background and strong knowledge of women’s hoops to turn the site’s prediction model into picks. 

Wetzel and Barzilai are 209-128-1 (+54.51 units) for ROI of 19.63% over the past two season on their women’s college basketball picks. On the SportsLine discord this season, Wetzel is 12-8, +2.94 units, +13.06% ROI on his women’s college basketball picks. 

Now, Wetzel and Barzilai have their sights set on UConn vs. South Carolina, and just revealed their Final Four picks and predictions. You can head to SportsLine now to see Wetzel and Barzilai’s picks. Here are several women’s college basketball odds and men’s college basketball lines for South Carolina vs. UConn:

Top UConn vs. South Carolina predictions

Wetzel and Barzilai are going Over on the point total (135.5), which has dropped a point since the opening line. These teams both have explosive offenses with UConn averaging 87.9 points per game, while South Carolina is right behind at 89.1. Both hit more than 50% of their shots from the field, and while these defenses will make them work, this game certainly has the ability to climb into the 140s or above. 

South Carolina has five players who average double figures, with Joyce Edwards (19.7 points per game) leading the way. Sarah Strong (18.6 ppg) and Azzi Fudd (17.5 ppg), meanwhile, carry the offensive load for the Huskies. You can see their spread picks at SportsLine.

How to make South Carolina vs. UConn picks

Wetzel and Barzilai have also found a critical X-factor that have them jumping all over one side of the spread, and have some recommendations for how to approach live picks and potential same-game-parlays. You can only see their picks at SportsLine.

So who wins UConn vs. South Carolina in the 2026 NCAA Women’s Tournament Final Four, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the experts on a 209-128 roll on their college basketball picks, and find out.