About DALY 2-EU²
DALY 2-EU (NCT04844866) is a pivotal, randomized, multi-center, open-label Phase II trial conducted in 12 countries within the EU, evaluating the safety and efficacy of genetically engineered autologous T-cells expressing anti-CD20 and anti-CD19 specific chimeric antigen receptor, zamtocabtagene autoleucel (zamto-cel), compared to chemoimmunotherapy (CIT), (rituximab, gemcitabine, and oxaliplatin (R.GemOx)) or polatuzumab vedotin plus bendamustine/rituximab (Pola-BR)), as a second-line therapy for primary relapsed/refractory large B-cell lymphoma (r/r LBCL). To our knowledge, is the only CAR-T randomized study in this patient population to date.