A man has died in hospital after he suffered a medical episode during an arrest in Sydney’s west.

Officers were called to a home in Homebush about 8.30am on Monday morning after reports of an alleged domestic/family violence-related incident, New South Wales police said.

Police said officers deployed OC spray, or pepper spray, while trying to arrest a man.

The man, 52, suffered a medical episode and was treated by paramedics at the scene before being taken to hospital in a critical condition.

The man died in hospital on Monday evening, police said.

Inquiries into the critical incident investigation will continue and the investigation will be subject to an independent review. A report will be prepared for the coroner.

The Law Enforcement Conduct Commission (LECC) said it had been notified of the critical incident by police.