The New York Knicks look to continue their home supremacy when they battle the Cleveland Cavaliers in an Eastern Conference matchup on the 2025 NBA Christmas Day schedule. Cleveland is coming off a 141-118 win over New Orleans on Tuesday, while New York dropped a 115-104 decision at Minnesota that same night. The Cavaliers (17-14), who are second in the Central Division, are 6-6 on the road this season. The Knicks (20-9), who are first in the Atlantic Division, are 14-2 on their home court. Evan Mobley (calf) is listed as questionable after missing the last five games.

Tipoff from Madison Square Garden in New York is set for noon ET. The Knicks lead the all-time series 122-109, but the Cavaliers have won four of the past five meetings. New York is a 5.5-point favorite in the latest Cavaliers vs. Knicks odds from SportsLine consensus, while the over/under for total points scored is 240.5. New York is at -217 on the money line (risk $217 to win $100). Before making any Knicks vs. Cavaliers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 10 of the 2025-26 NBA season on a sizzling 30-14 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Cavaliers vs. Knicks 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Knicks vs. Cavs:

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How to make Cavaliers vs. Knicks picks

SportsLine’s model is going Under on the total (240.5 points). New York went under in its last game and has gone under in two of three, while Cleveland hit the Under in its last road game. The SportsLine model is projecting Cleveland’s Donovan Mitchell to score 26.4 points on average and be one of five Cavaliers players to score 12.4 or more points. New York’s Jalen Brunson, meanwhile, is projected to have 28.3 points as six Knicks players score 10.5 points or more. However, just three total players are forecasted to reach 18 points as the Under hits well over 50% of the time.

It has also generated an against-the-spread pick that has all of the value. You can head to SportsLine to see the model’s NBA picks. 

So who wins Knicks vs. Cavaliers, and which side of the spread has all of the value? Visit SportsLine now to see which side of the Cavaliers vs. Knicks spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.