Welcome to Week 6, which is the most challenging scoring period so far this season. That’s because it’s the first week with four teams on a bye, and we have plenty of stars missing from Cincinnati, Detroit, Miami and Minnesota.

At quarterback, we’re down two must-start players in Joe Burrow and Jared Goff. The running backs missing are Jahmyr Gibbs, Chase Brown, Aaron Jones and Ollie Gordon II.

The receiver corps is decimated, with Ja’Marr Chase, Tee Higgins, Amon-Ra St. Brown, Jameson Williams, Justin Jefferson, and Malik Washington on a bye. And we don’t have Sam LaPorta, Mike Gesicki or T.J. Hockenson.

It was already tough for some Fantasy managers to fill out a starting lineup because of the injuries, but now it’s even more challenging in Week 6. But that’s why you’re here.

We’ve got you covered with all the starts, sits, and sleepers you need to win in Week 6. And don’t be surprised when players like Dameon Pierce, Germie Bernard and Kendrick Bourne help you earn a victory.

It’s about to get crazy in a lot of Fantasy leagues with four teams on a bye. So let’s make sure those lineups are ready to go.

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Chiefs (vs. LAC)

The Chargers could be without Ladd McConkey (foot), Quentin Johnston (chest) and Tre Harris (hamstring) in Week 6 against the Chiefs, who are coming off a bye. The Chargers also have a makeshift offensive line due to injuries and have scored 17 points or less in four of five games. Justin Herbert has also been sacked nine times in his past two games against Seattle and Denver, and the Chargers have four fumbles and three interceptions over that span. This should be a big week for the Chiefs DST.

Ravens (at CLE)
49ers (vs. WAS)
Colts (vs. TEN)

Jaguars (vs. HOU)

I thought the Jaguars’ DST had a chance to be dominant in Week 5 against Philadelphia, but Jacksonville managed just one sack and no turnovers, even though the Eagles scored just 17 points. The Jaguars have allowed 20 points or less in every game this season, but the Texans have scored 56 points in the past two games against Dallas and Tennessee. Houston hasn’t had a turnover in four games in a row, and C.J. Stroud has been sacked just seven times in his past three outings.