A medical jet with six people on board has gone missing near Nantucket while flying from Bermuda to Boston early Saturday, according to the U.S. Coast Guard and Federal Aviation Administration.

The FAA lost contact with the plane around 1 a.m. local time and issued a Search and Rescue Alert Notice for the Gulfstream G-100.

The search was being conducted off the coast of Nantucket, according to the U.S. Coast Guard Northeast District. The Coast Guard outlined the extensive assets involved in the search, including an HC-144 Ocean Sentry airplane, HC-130 Hercules airplane, MH-60 Jayhawk helicopter, a 47-foot Motor Lifeboat and the FRC William Sparling, a Sentinel-class fast response cutter.

The jet is registered to Latitutde Air Ambulance, according to the tail number provided by the U.S. Coast Guard.

The plane took off at about 11:40 p.m. ET on Friday, according to data from FlightAware.

Bermuda airport’s operator, Skyport, said in a statement to The Associated Press that the plane departed Bermuda’s L.F. Wade International Airport overnight for the flight to Massachusetts. The Canadian-registered air ambulance jet had four crew members and two passengers aboard.

It went missing after about 1 hour, 45 minutes in the air. FlightAware data shows it quickly dropped from about 24,000 feet in the air to 11,000 feet before losing contact.

The plane had been set to land at Boston’s Logan International Airport at about 1:30 a.m. local time.