Coyote vs. Acme hits theaters on August 28, 2026.

Resident Evil

The Resident Evil film franchise has grossed over $1.2 billion worldwide since the first film debuted in 2002, but an attempt to reboot it a few years ago floundered. Sony Pictures is trying again, this time tapping Zach Cregger—who wrote, produced, and directed last year’s Oscar-winning horror hit Weapons—for the project. The studio showed the first teaser for Cregger’s Resident Evil during CinemaCon in April and dropped the full trailer today at SDCC.

Per the official logline: “Resident Evil follows Bryan (Austin Abrams), a medical courier who unwittingly finds himself in a nonstop race for survival as one fateful, horrifying night collapses around him in chaos.” Joining Abrams (who also appeared in Weapons) in the main cast are Paul Walter Hauser as Carl, Zach Cherry as Dave, Kali Reis as Pauline, and Johnno Wilson as Max.

According to Cregger, this new film is not a direct game adaptation, but an original story with original characters set in the same fictional universe. Nor will it be like Weapons; Cregger’s Resident Evil vision, he said, is closer to Evil Dead II. But it would, he said, be “true to the spirit of the games.”

The new trailer firmly establishes our protagonist, Bryan, as a likable everyman working as a medical delivery driver to bring transplant organs to hospitals. It’s a cold winter night, with heavy snow falling, when he agrees to make an urgent delivery outside “the zone”—for double the pay—to Raccoon City General. While Bryan is driving and arguing with his pregnant girlfriend on the phone, a woman walks into the road, and he hits her.

We know she’s a zombie, but Bryan does not—although he’ll figure it out pretty quickly. We see him searching frantically for ammo in a nearby house where something very bad has clearly happened. The rest of the town is just as overrun, and according to Carl, “Everything that has happened in this town transpired in a matter of hours.” So much for Bryan’s extra run being “no sweat.”

Resident Evil opens in theaters on September 18, 2026.