Donald Trump on Thursday posted an AI-generated social media video portraying himself as a doctor who claims to have cured some of his most prominent celebrity critics – including Rosie O’Donnell – of the fictional condition “Trump derangement syndrome”.

Outside the AI fantasy, O’Donnell said her assessment of the president remained unchanged. In a statement, she offered her own diagnosis: “He’s quite ill-and getting worse daily. The 25th amendment exists for exactly this reason. Remove. Impeach. Convict.”

The testimonial-style video, shared on social media by @realDonaldTrump, features AI-generated versions of celebrities who have spoken out against the president and his administration, including Whoopi Goldberg, Edward Norton and Julia Roberts.

The video uses hyper-realistic, fabricated footage to portray celebrity figures as regretful of their antipathy toward the president.

“I couldn’t eat, I couldn’t sleep, constantly angry,” said a deepfake version of Robert De Niro. “I made everyone miserable around me.”

Sporting a white coat and stethoscope, AI “Dr Trump” says he was not confident he could help those afflicted with TDS, a term used by the president and his allies to accuse critics of being irrationally opposed to his agenda.

“They were so far gone, I wasn’t really sure,” the fake Trump says, before promoting his prescribed “treatment plan”.

Patients afflicted with “TDS” should “turn off fake news, say your prayers, and if you ever feel anxious, just have a Diet Coke like me, and you’re going to see a remarkable difference in your life,” says Trump.

Trump has enthusiastically dabbled in AI-generated content, some of it shocking, often to idealize his own presidency – or target his opponents. Earlier this year, Trump shared an image that depicted him as Jesus healing the sick. He deleted the post after a backlash from high-profile Christian commentators and allies, who called the image blasphemous.

In another, he portrayed himself as the Pope amid a feud with the pontiff, Leo XIV. Last year, he gleefully posted a fake Time magazine cover depicting him as a king wearing a crown. “Long live the king!” he declared.

In February, Trump shared a racist video portraying Barack Obama and Michelle Obama as apes, prompting furious backlash. He deleted the post but refused to apologize.

The White House has largely treated the posts as humorous and part of the president’s political messaging style. In response to the president’s latest video, Davis Ingle, a White House spokesperson, said posting it was Trump’s “right”.

“Trump Derangement Syndrome is a crippling disease that has unfortunately rotted the brains of many people,” he added.

Officials did not confirm whether the White House had contacted any of the actors depicted about using their likeness.