Tracing the Genetic Footprints of the UK National Health Service


The establishment of the UK National Health Service (NHS) in July 1948 was one of the most consequential health policy interventions of the twentieth century, providing universal and free access to medical care and substantially expanding maternal and infant health services. In this paper, we estimate the causal effect of the NHS introduction on early-life mortality and we test whether survival is selective. We adopt a regression discontinuity design under local randomization, comparing individuals born just before and just after July 1948. Leveraging newly digitized weekly death records, we document a significant decline in stillbirths and infant mortality following the introduction of the NHS, the latter driven primarily by reductions in deaths from congenital conditions and diarrhea. We then use polygenic indexes (PGIs), fixed at conception, to track changes in population composition, showing that cohorts born at or after the NHS introduction exhibit higher PGIs associated with contextually-adverse traits (e.g., depression, COPD, and preterm birth) and lower PGIs associated with contextually-valued traits (e.g., educational attainment, self-rated health, and pregnancy length), with effect sizes as large as 7.5% of a standard deviation. These results based on the UK Biobank data are robust to family-based designs and replicate in the English Longitudinal Study of Ageing and the UK Household Longitudinal Study. Effects are strongest in socioeconomically disadvantaged areas and among males. This novel evidence on the existence and magnitude of selective survival highlights how large-scale public policies can leave a persistent imprint on population composition and generate long-term survival biases.

Here is the link, via S.



Source link

  • Related Posts

    Key Oil Chokepoints in Mideast Face Disruption as Threats Mount

    (Bloomberg) — Shipping disruptions in key Middle East chokepoints intensified as the US-Iran war grinds on, with vessels in the Red Sea making unusual maneuvers, while visible traffic through the…

    Asian shares trade mixed after Wall Street climb, as Brent oil keeps rising

    TOKYO (AP) — Asian shares were trading mixed Wednesday following a rally on Wall Street, despite concerns about higher oil prices and inflation. Japan’s benchmark Nikkei 225 fell 0.2% to…

    Leave a Reply

    Your email address will not be published. Required fields are marked *

    You Missed

    Key Oil Chokepoints in Mideast Face Disruption as Threats Mount

    Watch: CN Tower zapped by lightning, city under severe thunderstorm watch

    Watch: CN Tower zapped by lightning, city under severe thunderstorm watch

    AJ, Hearn & Smith talk Prenga, Fury and becoming undisputed champion

    AJ, Hearn & Smith talk Prenga, Fury and becoming undisputed champion

    Threads Is Getting New Parental Control Features

    Threads Is Getting New Parental Control Features

    Pokémon World Championships Exclusive Plush Officially Revealed

    Pokémon World Championships Exclusive Plush Officially Revealed

    EU bids to finalise new Russia sanctions amid discontent from some member states – Europe live | Europe

    EU bids to finalise new Russia sanctions amid discontent from some member states – Europe live | Europe