The Eagles (11-6) and 49ers (12-5) are on a collision course and set to clash at Lincoln Financial Field on Sunday afternoon, and it offers the backdrop for a ton of points to be scored. The early betting lines are available, and according to BetMGM, the Super Bowl champs will open as a 3.5-point home favorite over a 49ers team hobbled on defense.  The 49ers are looking to regroup after the Seahawks’ 13-3 win over San Francisco on Saturday night.

San Francisco is already banged up on defense and will be without All-Pro linebacker Fred Warner. The 49ers are set to start preparation, and they’ll be without linebacker Tatum Bethune.

Bethune was forced to exit late in the fourth quarter of Saturday’s loss to Seattle after sustaining a groin injury, finishing the contest with seven tackles (two solo), including 1.0 sacks, and one pass defense. San Francisco could also be without Dee Winters (ankle), who was forced to exit in the second quarter. The potential loss of two starting linebackers is a massive blow to a San Francisco defense that is already without Warner (ankle – IR), pass rushers Mykel Williams (knee – IR) and Nick Bosa (knee – IR).

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With Bethune out, Eric Kendricks, Garret Wallow, and Curtis Robinson (who was inactive for Week 18) would all be in line for more defensive snaps at linebacker against an Eagles offense looking to establish the running game.

This article originally appeared on Eagles Wire: Tatum Bethune to miss game vs. Eagles with a groin injury