The Florida International Panthers face the UTSA Roadrunners in the 2025 First Responder Bowl on Friday night. FIU is coming off a 56-16 win at Sam Houston State on Nov. 29, while UTSA dropped a 27-24 decision to Army that same day. FIU (7-5), who finished tied for fourth in Conference USA at 5-3, have won four in a row. UTSA (6-6), who tied for sixth in the American Conference, have won two of three. Both sides are expected to be down multiple key players due to injuries and the transfer portal, with FIU particularly decimated in the secondary. FIU’s quarterback situation is a bit unclear as well after Keyone Jenkins and Joe Pesansky both dealt with injuries late in the season. Both could play in some capacity on Friday. 

Kickoff from Gerald J. Ford Stadium in Dallas is at 8 p.m. ET. The Roadrunners are 7-point favorites in the latest FIU vs. UTSA odds, while the over/under for total points scored is 61.5, up four from the opening line. Before making any UTSA vs. FIU picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. 

Now, the model has set its sights on FIU vs. UTSA. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for UTSA vs. FIU:

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How to make FIU vs. UTSA picks

SportsLine’s model is going Over (61.5) on the total. The Over has hit in six of FIU’s last 10 games, and in seven of UTSA’s last 10. 

The model has FIU quarterback Keyone Jenkins passing for more than 225 yards and two touchdowns, while UTSA quarterback Owen McCown is projected to throw for 290 yards and three touchdowns. The teams are projected to combine for 65 points as the Over clears in well over 50% of simulations. 

The model also says one side of the spread hits in well over 60% of simulations. You can see the model’s pick at SportsLine.  

So who wins FIU vs. UTSA, and which side of the spread hits in well over 60% of simulations? Visit SportsLine now to see which side of the FIU vs. UTSA spread to jump on, all from the advanced model that has simulated this matchup 10,000 times, and find out.