The NFL Week 15 schedule is full of playoff implications. Among them is the AFC West matchup between Justin Herbert and the Los Angeles Chargers vs. Patrick Mahomes and the Kansas City Chiefs. Los Angeles is in the thick of the AFC West race, while the Chiefs need a strong finish and a lot of help to reach the postseason for an 11th consecutive year. Kansas City is a 5.5-point favorite and is 4-6 against the spread in its last 10 games, while Los Angeles is 3-6-1 ATS in their last 10 and coming off a short week and an overtime game no less. The Chargers won the last meeting, 27-21, in Brazil on Sept. 5.

There are a number of other solid matchups on the Week 15 NFL schedule, including Bills (-1.5) vs. Patriots, Ravens (-2.5) vs. Bengals, Packers (-2.5) vs. Broncos, Lions vs. Rams (-6) and Colts vs. Seahawks (-13.5). Before locking in any Week 15 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 on a 50-35 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has scoured the Week 15 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of nearly 25-1. You can only see the model’s Week 15 NFL picks at SportsLine.

Top Week 15 NFL picks

After simulating every game 10,000 times, the model is high on the Dallas Cowboys (-5.5, 47.5) to cover against the Minnesota Vikings on Sunday Night Football. 

The Cowboys are led by quarterback Dak Prescott. In 13 games this season, he has completed 69% of his passes for 3,637 yards and 26 touchdowns with 10 interceptions and a 100.2 rating. He has also rushed 44 times for 138 yards (3.1 average) and two touchdowns. In a 44-30 loss at Detroit in Week 14, he completed 31 of 47 passes for 376 yards and one touchdown with two interceptions.

Bet Prescott to go Over 37.5 yards for longest completion using the latest DraftKings promo code, which offers $200 in bonus bets if your bet wins:

The model has Dallas winning outright over 70% of the time and covering in nearly 60% of simulations in an A-rated spread pick. See which other NFL parlay picks to make here, and new users can bet the Cowboys to cover using the DraftKings promo code, which offers $200 in bonus bets if your bet wins:

How to make Week 15 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will easily cover. You can only see the model’s Week 15 NFL best bets and NFL parlay at SportsLine.

What are the model’s top Week 15 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 15 NFL best bets from a model on a 50-35 run on top-rated picks, and find out.