The 2025 women’s NCAA basketball tournament is underway, and the field is down to 12 teams looking to make their mark on history. The UCLA Bruins clinched the overall No. 1 seed after a resounding Big 10 tournament win, and spent 12 weeks at No. 1 in the AP poll, while across the bracket is reigning champion South Carolina, looking to repeat history and give head coach Dawn Staley her fourth ring.

The USC Trojans and Texas Longhorns round out the top seeds, but it is 2-seed Uconn that is the current betting favorites, especially after an injury to star Trojans guard JuJu Watkins shook up the Spokane Regional quadrant of the bracket.

The road to the Final Four now continues on Saturday and Sunday. Watch every game on ABC, ESPN and ESPN+.

Odds are accurate as of publication time. All times eastern. For the latest odds, go to ESPN BET.

Friday – Sweet 16 Day 1

(3) North Carolina Tar Heels
(2) Duke Blue Devils -5.5
Regional 2 in Birmingham, 2:30 p.m. Legacy Arena at BJCC, Birmingham, AL

North Carolina: 27-7, 13-5 in ACC play
Duke: 26-7, 14-4 in ACC play

Odds by ESPN BET
Moneyline: Duke (-240), North Carolina (+200) Total: 121.5

BPI Projection: Duke by 7.5, straight up: 75.8%

(4) Maryland Terrapins
(1) South Carolina Gamecocks -17.5
Regional 2 in Birmingham, 5 p.m. Legacy Arena at BJCC, Birmingham, AL

Maryland: 23-7, 13-5 in Big Ten play
South Carolina: 30-3, 15-1 in SEC play

Odds by ESPN BET
Moneyline: South Carolina (-4000), Maryland (+1300) Total: 149.5

BPI Projection: South Carolina by 16.9, straight up: 92.9%

(3) LSU Tigers -3.5
(2) NC State Wolfpack
Regional 1 in Spokane, 7:30 p.m. Spokane Arena, Spokane, WA

LSU: 30-5, 12-4 in SEC play
NC State: 26-6, 16-2 in ACC play

Odds by ESPN BET
Moneyline: LSU (-170), NC State (+145) Total: 152.5

BPI Projection: LSU by 3.7, straight up: 63.7%

(5) Ole Miss Rebels
(1) UCLA Bruins -8.5
Regional 1 in Spokane, 10 p.m. Spokane Arena, Spokane, WA

Ole Miss: 20-10, 10-6 in SEC play
UCLA: 30-2, 15-2 in Big Ten play

Odds by ESPN BET
Moneyline: UCLA (-380), Ole Miss (+290) Total: 134.5

BPI Projection: UCLA by 9.3, straight up: 80.4%

Saturday – Sweet 16 Day 2

(3) Notre Dame Fighting Irish -7.5
(2) TCU Horned Frogs
Regional 3 in Birmingham, 1 p.m. Legacy Arena at BJCC, Birmingham, AL

Notre Dame: 26-5, 16-2 in ACC play
TCU: 31-3, 16-2 in Big 12 play

Odds by ESPN BET
Moneyline: Notre Dame (-300), TCU (+250) Total: 144.5

BPI Projection: Notre Dame by 9, straight up: 79.7%

(5) Tennessee Lady Volunteers
(1) Texas Longhorns -7.5
Regional 3 in Birmingham, 3:30 p.m. Legacy Arena at BJCC, Birmingham, AL

Tennessee: 22-9, 8-8 in SEC play
Texas: 31-3, 15-1 in SEC play

Odds by ESPN BET
Moneyline: Texas (-340), Tennessee (+270) Total: 154.5

BPI Projection: Texas by 8.2, straight up: 77.7%

(3) Oklahoma Sooners
(2) UConn Huskies -15.5
Regional 4 in Spokane, 5:30 p.m. Spokane Arena, Spokane, WA

Oklahoma: 25-7, 11-5 in SEC play
Uconn: 31-3, 18-0 in Big East play

Odds by ESPN BET
Moneyline: Uconn (-1600), Oklahoma (+800) Total: 153.5

BPI Projection: Uconn by 12.9, straight up: 87.8%

(5) Kansas State Wildcats
(1) USC Trojans -1.5
Regional 4 in Spokane, 8 p.m. Spokane Arena, Spokane, WA

Kansas State: 26-7, 13-5 in Big 12 play
USC: 28-3, 16-1 in Big Ten play

Odds by ESPN BET
Moneyline: USC (-125), Kansas State (+105) Total: 140.5

BPI Projection: USC by 6.3, straight up: 72.4%