Then, 28 days after leaving, Spike was rescued from a horde of infected by Sir Jimmy Crystal (Jack O’Connell), another original survivor who turned out to be the leader of a barbaric cult. That’s where the sequel picks up. Spike, Kelson, and Crystal will play major roles in The Bone Temple. Per the official premise:

Dr. Kelson finds himself in a shocking new relationship—with consequences that could change the world as they know it—and Spike’s encounter with Jimmy Crystal becomes a nightmare he can’t escape. In the world of The Bone Temple, the infected are no longer the greatest threat to survival—the inhumanity of the survivors can be stranger and more terrifying.

Samson the Alpha Zombie is back, too. The cast also includes Erin Kellyman, Emma Laird, and Maura Bird as Jimmy Ink, Jimmima, and Jimmy Jones, all members of Crystal’s cult. Best of all, Cillian Murphy will reprise his 28 Days Later/28 Weeks Later starring role as intrepid bike courier Jim, who miraculously survived the first two movies and, apparently, the ensuing 28 years.

The trailer opens with an exchange between Kelson and Crystal, in which the latter asks if Kelson is “Old Nick,” i.e., Satan. It’s a reasonable assumption, given that morbid bone temple. We also see Spike joining Crystal’s ranks and Kelson remembering the happier past before sharing a moment of truce with Samson. “I believe the infection can be treated,” Kelson says later, and in the final scene, we see him give Samson an injection representing “a leap into the unknown.” Will it really cure Samson? We know there’s already another film in the works, so that might be an interesting twist.

Look for 28 Years Later: Bone Temple to hit theaters on January 16, 2026.